Abstract:

Metabolomics is an emerging discipline for detecting the metabolites of all cellular processes after pathological stimulation or genetic modification. In this paper, we systematically review the application of metabolomics in the diagnosis and pathological mechanism of glaucoma patients in recent years. We summarized the similarities and differences of metabolitic changes in glaucoma diseases by various metabolomics techniques in different tissues.The result presented may enhance our understanding in the diagnosis and progression of glaucoma as well as in finding the biological indicators for early diagnosis and prognosis. The general feature of metabolites changes in glaucoma are increased expression of glutamate, sphingosine, phosphocholine, phosphatidylcholine, short\|chain unsaturated fatty acids and decreased expression of long\|chain unsaturated fatty acids and spermine etc.(Int Rev Ophthalmol, 2019, 43:   294-299)